Nkx2.6 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA575416-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA575416 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Nkx2.6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NKX2-6
Gene Alias
AV044928; CSX2; CTHM; Drosophila NK2 transcription factor related, locus 6; homeobox protein NK2 homolog F; homeobox protein NK-2 homolog F; homeobox protein NKX2.6; homeobox protein Nkx-2.6; NK2 homeobox 6; NK2 transcription factor related, locus 6; Nkx2.6; Nkx-2.6; Nkx2-6; Nkx2f; NKX4-2; tinman; tinman paralog; Tix
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
137814, 18092, 364418
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide; pH 7.2
Gene Accession No.
A6NCS4, P43688
Gene Symbols
NKX2-6
Immunogen
Synthetic peptide corresponding to amino acids 111-160 of Human Nkx2.6.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
- Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas.Nkx-2.5, also designated cardiac specific homeobox protein (Csx), is a homolog of the Drosophila tinman protein and is essential for normal cardiovascular development
- Expression of Nkx-2.5 during cardiomyogenesis is required for cardiac septation, in which a single atrium and ventricle are separated into four chambers
- Nkx-2.5 binds to DNA as a monomer, a homodimer or as a heterodimer with Nkx-2.3 or Nkx-2.6, which suggests that the specific protein-protein interactions of Nkx-2.5 are involved in its transcriptional regulatory function
- Nkx-2.6, also a homolog of the Drosophila tinman protein, is expressed in the caudal pharyngeal pouches,the caudal heart progenitors, the sinus venosus, the outflow tract of the heart and in a short segment of the gut between stages E8.5 and E10.5 of embryogenesis
- Expression of Nkx-2.6 overlaps with that of Nkx-2.5 in the pharynx and heart
- However, Nkx-2.6 mutant mice are viable and fertile, which suggests that Nkx-2.6 plays a compensatory function to Nkx-2.5.