SIX5 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA575417-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA575417 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
SIX5
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Six5
Gene Alias
BOR2; DM locus-associated homeodomain protein; DM locus-associated homeodomain protein homolog; DMAHP; dystrophia myotonica-associated homeodomain protein; homeobox protein SIX5; MDMAHP; Sine oculis homeobox homolog 5; sine oculis-related homeobox 5; sine oculis-related homeobox 5 homolog; SIX homeobox 5; Six5; TrexBF
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
147912, 20475, 308406
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide; pH 7.2
Gene Accession No.
P70178, Q8N196
Gene Symbols
Six5
Immunogen
Synthetic peptide corresponding to amino acids 205-256 of Human Six5.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
- Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye
- Localized to the cytoplasm in early development and to the nucleus in the later stages of development, Six5 is involved in regulation of organogenesis and in maintenance of retinal formation
- Six5 is able to bind the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA
- Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins
- Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia
- Two isoforms exist due to alternative splicing events.