Cortactin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA577964-Each-of-1 | In Stock | ₹ 52,332.00 |
PIPA577964 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,332.00
GST (18%): ₹ 9,419.76
Total Price: ₹ 61,751.76
Antigen
Cortactin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cttn
Gene Alias
1110020L01Rik; amplaxin; cortactin; Cttn; Cttnb; EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); FLJ34459; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); oncogene EMS1; Oncogene SRC8; Src substrate cortactin; src8; Unknown (protein for MGC:137923)
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2017
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
0.31 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q14247
Gene Symbols
Cttn
Immunogen
Recombinant protein encompassing a sequence within the center region of human Cortactin. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Control: 293T, HeLa Predicted Reactivity: Mouse (80%), Rhesus Monkey (95%) Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Cortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src
- It contributes to the organization of the actin cytoskeleton and cell shape
- Cortactin also plays a role in the formation of lamellipodia and cell migration
- It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation
- Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains
- NTA associates with the Arp2/3 and WASP complex at F-actin branches
- Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells
- Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases.