SKI Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA578166-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA578166 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
SKI
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SKI
Gene Alias
2310012I02Rik; 2610001A11Rik; AA062172; AA589460; BC004088; C-ski; Proto-oncogene c-Ski; RGD1565591; SGS; SKI; Ski oncogene; ski oncoprotein; SKI proto-oncogene; ski sarcoma viral oncogene homolog; ski sarcoma viral oncogene homolog (avian); SKV; Sloan-Kettering viral oncogene homolog; v-ski avian sarcoma viral oncogene homolog
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6497
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
0.43 mg/mL
Formulation
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
P12755
Gene Symbols
SKI
Immunogen
Recombinant protein encompassing a sequence within the center region of Human SKI. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Control: HCT116, HCT116 nuclear extract Predicted Reactivity: Mouse (90%), Chicken (80%) Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis
- This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN
- Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes
- Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.