IKK epsilon Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA587387-Each-of-1 | In Stock | ₹ 47,036.50 |
PIPA587387 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
IKK epsilon
Classification
Polyclonal
Conjugate
Unconjugated
Gene
IKBKE
Gene Alias
AW558201, I-kappa-B kinase epsilon, Ikbke, IKKE, IKK-E, IKKepsilon, IKK-epsilon, IKKI, IKK-i, IKK-related kinase epsilon, inducible I kappa-B kinase, inducible IkappaB kinase, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, inhibitor of kappaB kinase epsilon, inhibitor of nuclear factor kappa-B kinase subunit epsilon, KIAA0151, RP11-534L20.1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
363984, 56489, 9641
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Western Blot
Concentration
2.06 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
Q14164, Q9R0T8
Gene Symbols
IKBKE
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 497-716 of human IKKε, (NP_0547211)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: SW480, DU145, MCF7, Mouse liver; Cellular Location: Cytoplasm, Nucleus, PML body Immunogen sequence: SRLRTLAEVL SRCSQNITET QESLSSLNRE LVKSRDQVHE DRSIQQIQCC LDKMNFIYKQ FKKSRMRPGL GYNEEQIHKL DKVNFSHLAK RLLQVFQEEC VQKYQASLVT HGKRMRVVHE TRNHLRLVGC SVAACNTEAQ GVQESLSKLL EELSHQLLQD RAKGAQASPP PIAPYPSPTR KDLLLHMQEL CEGMKLLASD LLDNNRIIER LNRVPAPPDV IKBKE is an activator of nuclear factor-kappa-B
- Over expression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death
- NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses
- NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli
- NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity
- Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma
- A novel molecule in the IKK complex was recently identified and designated IKK-iota/IKK-i
- IKK epsilon is required for the activation of NF-kappa-B by PMA and T cell receptors but not by TNF-a and IL-1
- IKK-iota/IKK-i message is expressed in a variety of tissues and is inducible by TNF-a, IL-1, and LPS.