CRM1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA587417-Each-of-1 | In Stock | ₹ 47,481.50 |
PIPA587417 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
CRM1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
XPO1
Gene Alias
AA420417, chromosome region maintenance 1 homolog, chromosome region maintenance 1 protein homolog, CRM1, emb, Exp1, exportin 1, exportin 1 (CRM1 homolog, yeast), exportin 1 (CRM1, yeast, homolog), exportin 1, CRM1 homolog, exportin 1, CRM1 homolog (yeast), exportin-1, exportin-1 (required for chromosome region maintenance), Xpo1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
103573, 7514
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.85 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
O14980, Q6P5F9
Gene Symbols
XPO1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 964-1064 of human CRM1/CRM1/XPO1 (NP_0033911)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: U-87MG, B-cell, Mouse liver; Cellular Location: Cajal body, Cytoplasm, Nucleus, nucleolus, nucleoplasm Immunogen sequence: PGNPVNNQIF LQEYVANLLK SAFPHLQDAQ VKLFVTGLFS LNQDIPAFKE HLRDFLVQIK EFAGEDTSDL FLEEREIALR QADEEKHKRQ MSVPGIFNPH E Exportin - 1 (XPO1) mediates the nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NES) and RNAs
- In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP)
- Docking of this complex to the nuclear pore complex is mediated through binding to nucleoproteins
- Upon transit of a nuclear complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor
- The directionality of the nuclear export is thought to be conferred by an asymmetric distribution of the GTP and GDP bound forms of Ran between the cytoplasm and nucleus.