NDUFAF2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA589734-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA589734 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
NDUFAF2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Ndufaf2
Gene Alias
1810058I14Rik, B17.2L, B17.2-like, B172L, B172-like, C86051, mimitin, mimitin, mitochondrial, MMTN, Myc-induced mitochondria protein, Myc-induced mitochondrial protein, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2, NADH dehydrogenase (ubiquinone) complex I, assembly factor 2, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2, NADH dehydrogenase 1 alpha subcomplex assembly factor 2, NADH:ubiquinone oxidoreductase complex assembly factor 2, NDUFA12L, NDUFA12-like protein, Ndufaf2, RGD1560158
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
361894, 75597, 91942
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
Q59J78, Q8N183
Gene Symbols
Ndufaf2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-169 of human NDUFAF2 (NP_7775491)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MGWSQDLFRA LWRSLSREVK EHVGTDQFGN KYYYIPQYKN WRGQTIREKR IVEAANKKEV DYEAGDIPTE WEAWIRRTRK TPPTMEEILK NEKHREEIKI KSQDFYEKEK LLSKETSEEL LPPPVQTQIK GHASAPYFGK EEPSVAPSST GKTFQPGSWM PRDGKSHNQ; Positive Samples: HepG2, HeLa, SH-SY5Y, Rat heart; Cellular Location: Mitochondrion Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC)
- Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells
- Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kappa-B-related pathway
- It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis
- Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.