AIRE Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595921-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA595921 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
AIRE
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Aire
Gene Alias
Aire, AIRE protein, AIRE1, APECED, APECED protein, APECED protein homolog, APS1, APSI, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog, Autoimmune regulator, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), autoimmune regulator AIRE1a, LOW QUALITY PROTEIN: autoimmune regulator, OTTHUMP00000109529, PGA1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11634, 294328, 326
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1.57 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
O43918, Q9Z0E3
Gene Symbols
Aire
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 30-130 of human AIRE (NP_0003741)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: MCF7, U-937, HT-29, OVCAR3, SW620, Mouse kidney, Mouse liver; Cellular Location: Cytoplasm, Nucleus Immunogen sequence: HALADHDVVP EDKFQETLHL KEKEGCPQAF HALLSWLLTQ DSTAILDFWR VLFKDYNLER YGRLQPILDS FPKDVDLSQP RKGRKPPAVP KALVPPPRLP T AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression
- A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes
- It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP
- Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD)
- AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity
- Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).