PSMC2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596024-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA596024 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
PSMC2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PSMC2
Gene Alias
26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, 26S proteasome regulatory subunit 7, mammalian suppressor of sgv-1 of yeast, MGC3004, MSS1, Nbla10058, protease 26S subunit 7, proteasome (prosome, macropain) 26S subunit, ATPase 2, proteasome (prosome, macropain) 26S subunit, ATPase, 2, proteasome 26S subunit ATPase 2, proteasome 26S subunit, ATPase 2, proteasome 26S subunit, ATPase, 2, Protein MSS1, PSMC2, putative protein product of Nbla10058, S7, testis secretory sperm-binding protein Li 197a
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19181, 25581, 5701
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.98 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
P35998, P46471, Q63347
Gene Symbols
PSMC2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PSMC2 (NP_0027941)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT; Positive Samples: HepG2, SW620, BT474, DUCAR3, 293T, mouse spleen, mouse brain, rat testis, rat liver, BT-474, OVCAR3, NCI-H460; Cellular Location: Cytoplasm, Nucleus, P-body Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors
- The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus
- Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum
- The 26S proteasome is an ATP-dependent, multisubunit (∽31), barrel-shaped molecular machine with an apparent molecular weight of ∽2.5 MDa
- It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes
- The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit
- An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation
- Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway
- Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.