p70 S6 Kinase Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596090-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA596090 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
p70 S6 Kinase
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RPS6KB1
Gene Alias
10539, 2610318I15Rik, 4732464A07Rik, 70 kDa ribosomal protein S6 kinase 1, 7084, 70kDa, 7-10, AA959758, AI256796, AI314060, CG10539, CG10539-PA, CG10539-PB, Dmel\CG10539, Dmel_CG10539, Dp70[s6k], Dp70S6k, dps6k, dS6 kinase, dS6K, d-S6K, dS6K1, EC 2.7.11.1, fs(3)07084, hypothetical protein, kinase p70S6K, KS6B1, l(3)07084, p70 p70-S6K, p70 ribosomal S6 kinase, p70 ribosomal S6 kinase alpha, p70 S6 kinase, p70 S6 kinase 1, p70 S6 kinase alpha, p70 S6 kinase, alpha, p70 S6K, p70 S6KA, p70 S6K-alpha, p70(S6K)-alpha, p70/85s6k, p70/S6K, p70[S6 kinase], p70[S6k], p70[S6kinase], p70-alpha, p70S6 kinase, p70S6k, p70-S6K, p70-S6K 1, p70S6K kinase, p70s6k protein kinase homolog, P70S6K1, p70S6K-alpha, p80-S6K 1, p85 p85S6K, Pk?6, Pk64F, protein kinase-like 64F, PS6K, p-S6K, ribosomal protein S6 kinase, ribosomal protein S6 kinase B1, ribosomal protein S6 kinase beta-1, Ribosomal protein S6 kinase I, ribosomal protein S6 kinase polypeptide 1, ribosomal protein S6 kinase, 70kD, polypeptide 1, ribosomal protein S6 kinase, 70kDa, polypeptide 1, ribosomal protein S6 kinase, polypeptide 1, ribosomal S6 protein kinase, Rps6kb1, RPS6-p70-protein kinase, S6 K, S6 kinase, s6k, S6K kinase, S6K1, s6k11, S6K-beta-1, S6kinase, S6-kinase, S6k-PA, S6k-PB, serine/threonine kinase 14 alpha, serine/threonine-protein kinase 14A, STK14A
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6198, 72508, 83840
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.56 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
P23443, P67999, Q8BSK8
Gene Symbols
RPS6KB1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 421-520 of human p70 S6 Kinase 1 (NP_0031521)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Raji, MCF7, A-549, PC-3, DU145, Mouse brain, Mouse kidney; Cellular Location: Cell junction, Cytoplasm, Mitochondrion outer membrane, Mitochondrion, Nucleus, synapse, synaptosome Immunogen sequence: SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein
- p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair
- p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis
- The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation
- Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.