Podoplanin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA589123-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA589123 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Podoplanin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PDPN
Gene Alias
29kDa cytosolic podoplanin intracellular domain, Aggrus, CTA-520D8.1, E11, E11 antigen epitope, epithelial cell surface transmembrane protein antigen, glycoprotein 36, Glycoprotein 38, glycoprotein, 36-KD, GP36, Gp38, GP40, HT1A-1, hT1alpha-1, hT1alpha-2, lung type I cell membrane associated glycoprotein, lung type-I cell membrane-associated glycoprotein (T1A-2), Ots8, OTS-8, OTTHUMP00000009640, OTTHUMP00000044504, PA2.26, PA2.26 antigen, PDPN, PICD, Podoplanin, PSEC0003, PSEC0025, pulmonary type I alveolar epithelial cell transmembrane differentiation marker, RANDAM-2, RP23-348F1.2, RTI140, RTI40, T1a, T1A2, T1A-2, T1alpha, T1-alpha, TI1A, Transmembrane glycoprotein E11, type I cell 40 kDa protein
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10630, 14726, 54320
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
2.01 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
Q62011, Q64294, Q86YL7
Gene Symbols
PDPN
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 23-131 of human Podoplanin (NP_0064653)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Mouse lung, Mouse brain, Rat kidney; Cellular Location: Cell projection, Membrane, Single-pass type I membrane protein, filopodium membrane, lamellipodium membrane, microvillus membrane, ruffle membrane Immunogen sequence: ASTGQPEDDT ETTGLEGGVA MPGAEDDVVT PGTSEDRYKS GLTTLVATSV NSVTGIRIED LPTSESTVHA QEQSPSATAS NVATSHSTEK VDGDTQTTVE KDGLSTVTL Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight
- Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs
- Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells
- As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes
- Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential
- Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue
- Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells
- Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC
- Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm
- Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.