ACK1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596151-Each-of-1 | In Stock | ₹ 47,036.50 |
PIPA596151 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
ACK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TNK2
Gene Alias
ACK, ACK1, Ack-1, Activated CDC42 kinase 1, activated Cdc42-associated kinase 1, activated p21cdc42Hs kinase, Cdc42 GTPase-inhibiting protein, Cdgip, Non-receptor protein tyrosine kinase Ack, p21cdc42Hs, P21cdc42Hs kinase, Pyk1, Tnk2, tnk2 {ECO:0000250, tyrosine kinase non receptor 2, tyrosine kinase non-receptor protein 2, tyrosine kinase, non-receptor, 2, UniProtKB:Q07912}
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10188, 303882, 51789
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.32 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
O54967, Q07912, Q5U2X5
Gene Symbols
TNK2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 920-1038 of human TNK2 (NP_0057723)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: KANFSTNNSN PGARPPPPRA TARLPQRGCP GDGPEAGRPA DKIQMAMVHG VTTEECQAAL QCHGWSVQRA AQYLKVEQLF GLGLRPRGEC HKVLEMFDWN LEQAGCHLLG SWGPAHHKR Positive Samples: SW620, HT-29, MCF7, Raji; Cellular Location: Cell junction, Cell membrane, Cytoplasmic side, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Endosome, Membrane, Nucleus, Peripheral membrane protein, adherens junction, clathrin-coated pit, clathrin-coated vesicle TNK2 (ACK) (activated Cdc42-associated kinase) is a non-receptor tyrosine kinase that signals downstream of Cdc42
- TNK2 is known to be involved in tumorigenesis and metastasis, particularly in prostate cancer
- Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1
- May be involved both in adult synaptic function and plasticity and in brain development
- Activates AKT1 by phosphorylating it on 'Tyr-176'
- Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs)
- Phosphorylates WWOX on 'Tyr-287'
- Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins
- Contributes to the control of AXL receptor levels
- Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR
- Phosphorylates WASP.