KPNA6 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596654-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA596654 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
KPNA6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KPNA6
Gene Alias
FLJ11249, importin alpha 7 subunit, importin alpha-S2, Importin subunit alpha-7, importin-alpha-S2, IPOA7, karyopherin (importin) alpha 5, karyopherin (importin) alpha 6, karyopherin alpha 6, karyopherin alpha 6 (importin alpha 7), karyopherin subunit alpha 6, karyopherin subunit alpha-6, Kpna5, Kpna6, KPNA7, MGC17918, NPI-2, RP4-622L5.1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16650, 23633
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1.25 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
O35345, O60684
Gene Symbols
KPNA6
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 277-536 of human KPNA6 (NP_0364481)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: SYLSDGPNEK IQAVIDSGVC RRLVELLMHN DYKVASPALR AVGNIVTGDD IQTQVILNCS ALPCLLHLLS SPKESIRKEA CWTISNITAG NRAQIQAVID ANIFPVLIEI LQKAEFRTRK EAAWAITNAT SGGTPEQIRY LVSLGCIKPL CDLLTVMDSK IVQVALNGLE NILRLGEQEG KRSGSGVNPY CGLIEEAYGL DKIEFLQSHE NQEIYQKAFD LIEHYFGVED DDSSLAPQVD ETQQQFIFQQ PEAPMEGFQL; Positive Samples: BT-474, SW620, U-251MG, Mouse testis Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism
- The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC
- KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6
- Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation
- KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.