TAB182 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA599724-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA599724 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
TAB182
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TNKS1BP1
Gene Alias
182 kDa tankyrase-1-binding protein; KIAA1741; TAB182; tankyrase 1 binding protein 1; tankyrase 1 binding protein 1, 182kDa; tankyrase 1-binding protein of 182 kDa; testis secretory sperm-binding protein Li 206a; TNKS1BP1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
85456
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q9C0C2
Gene Symbols
TNKS1BP1
Immunogen
A synthesized peptide derived from human TNKS1BP1(Accession Q9C0C2), corresponding to amino acid residues H1605-A1655.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total TAB182
- TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins
- Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor)
- Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation
- TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain
- This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres
- TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.