PK101050UL
MilliporeSigma™ anti-PhosphoDetect Syk (pTyr525/526), Polyclonal
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PK101050UL-Each-of-1 | In Stock | ₹ 37,706.63 |
PK101050UL - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,706.63
GST (18%): ₹ 6,787.193
Total Price: ₹ 44,493.823
Antigen
PhosphoDetect™ Syk (pTyr525/526)
Classification
Polyclonal
Formulation
In 150mM NaCl, 10mM sodium HEPES, 100μg/mL BSA, 50% glycerol, pH 7.5.
Immunogen
a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr525/526phosphorylation sites of human Syk
Regulatory Status
RUO
Test Specificity
Recognizes the ∽72kDa Syk protein phosphorylated at Tyr525/526in human Syk or Tyr519/520in mouse Syk in 293T cells expressing wild-type Syk and CD8.
Content And Storage
−20°C
Isotype
IgG
Applications
ELISA, Immunoblot, Immunoblot
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
50 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Purified
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Description
- Specifically detects PhosphoDetect™ Syk (pTyr 525/526 ) Clone: in Human, Mouse samples, and it is validated for ELISA, Immuno Blotting Syk is a protein tyrosine kinase that is widely expressed and plays a key role in hematopoietic cell signaling
- Syk is reported to interact with immunoreceptor tyrosine-based activation motifs (ITAMs) found in the cytoplasmic domains of immune receptors
- This interaction serves to couple activated immune receptors to downstream signaling events that mediate diverse cellular responses, such as proliferation, differentiation, and phagocytosis
- Syk is also reported to act as a potential tumor suppressor in human breast carcinomas
- Phosphorylation of Tyr 525/526 , located in the activation loop of human Syk, is required for Syk activity.