Epredia™ Lab Vision™ β-Catenin Rabbit Monoclonal Antibody

Description

• The catenins (α, β and γ) are ubiquitously expressed cytoplasmic proteins associated with E-cadherin at cellular junctions
• β-catenin also binds to N-cadherin and co-immunoprecipitates with APC
• Cadherin/catenin complexes are linked to the cytoskeleton via a direct association between α-actinin and α-catenin
• Increased tyrosine phosphorylation can disrupt catenin-cadherin complexes, influencing cellular adhesion
• Mutations in the catenin gene, CTNNB1, have been implicated in its accumulation and various forms of carcinomas
• Host Species: Rabbit Clone: E247 Species Reactivity: Human
• Others not known
• Immunogen: A synthetic peptide derived from near the N-terminus of human β-catenin Molecular Weight: 92 kDa Positive Control: Breast CA Cellular Localization: Cell Membrane Recommended for: Immunohistochemistry (Formalin/paraffin)