Estrogen Receptor (SP1) Rabbit Monoclonal Antibody, Epredia™

Description

• Description Recognizes a protein of 67 kDa, which is identified as estrogen receptor (ER) alpha
• The ER gene consists of more than 140kb of genomic DNA divided into 8 exons, and is translated into a protein with six functionally discrete domains, labeled A through F
• This antibody strongly stains the nucleus of epithelial cells in breast carcinomas
• The ER is an important regulator of growth and differentiation in the mammary gland
• Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g
• tamoxifen) therapy
• Host Species: Rabbit Clone: SP1 Isotype: IgG Species Reactivity: Human, Mouse and Hamster
• Others not tested
• Epitope: C-terminus Immunogen: Synthetic peptide derived from C-terminal of human estrogen receptor Molecular Weight: 67 kDa Positive Control: Breast CA, MCF-7 cells Cellular Localization: Nuclear Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting Immunofluorescence (Not verified) Flow Cytometery (Not verified)