RM9108R1
Epredia™ Lab Vision™ ALK (Anaplastic Lymphoma Kinase)/p80 Rabbit Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
ALK (Anaplastic Lymphoma Kinase)/p80
Classification
Monoclonal
Conjugate
Unconjugated
Immunogen
Recombinant protein corresponding to a region, which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript
Regulatory Status
IVD
Primary or Secondary
Primary
Form
Prediluted
Applications
Immunohistochemistry (Paraffin)
Clone
SP8
Host Species
Rabbit
Quantity
1 mL
Research Discipline
Cancer and Tumor Biology
Target Species
Human
Isotype
IgG
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Description
- Description Recognizes a human p80 protein, identified as a hybrid of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in 30-50% of CD30+ large cell lymphomas (1)
- This rabbit monoclonal antibody can be used to detect p80 in these lymphomas and may also be used to detect a recently described subtype of large B cell lymphoma, which expresses the full-length ALK protein (2)
- Host Species: Rabbit Clone: SP8 Isotype: IgG Species Reactivity: Human
- Others not tested
- Epitope: Not determined Immunogen: Recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript Positive Control: Anaplastic lymphoma Cellular Localization: Cytoplasmic + nuclear Clone SP8 is excellent for staining of formalin/paraffin with no special pretreatment Recommended for: Immunohistochemistry (Formalin/paraffin)