ST107050UG
MilliporeSigma™ anti-Tiam1, Polyclonal
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ST107050UG-Each-of-1 | In Stock | ₹ 26,027.16 |
ST107050UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 26,027.16
GST (18%): ₹ 4,684.889
Total Price: ₹ 30,712.049
Antigen
Tiam1
Classification
Polyclonal
Formulation
In Tris-Citrate/phosphate, pH 7.0-8.0.
Immunogen
a synthetic peptide corresponding to amino acids from the C-terminal domain of human Tiam1
Regulatory Status
RUO
Test Specificity
Recognizes the ∽200kDa Tiam1 protein in Jurkat and NIH3T3 cells.
Content And Storage
2°C to 8°C
Isotype
IgG
Applications
Immunoblot
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Purified
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Description
- Specifically detects Tiam1 Clone: in Human, Mouse samples, and it is validated for Immuno Blotting Tiam1 (T-cell lymphoma invasion and metastasis 1) was originally identified by its ability to induce invasion by T-lymphoma cells when amplified
- Tiam1 is a specific guanine nucleotide exchange factor (GEF) for the GTPase, Rac
- By activating Rac1, Tiam1 regulates many cellular functions including actin cytoskeleton dynamics, cell proliferation, and cell survival
- Tiam1 activity is regulated by its translocation to the membrane and the subsequent binding of its PH domain to phosphatidylinositol-3,4,5-triphosphate
- Tiam1 is cleaved in a caspase-dependent manner in apoptotic cells, rendering it inactive as a result of an inability to translocate to the plasma membrane.