72-545
Tocris Bioscience™ ARCC 4
Manufacturer: Tocris Bioscience™
CAS Number: 1973403-00-7
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 72-545-Each-of-1 | In Stock | ₹ 46,814.00 |
72-545 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,814.00
GST (18%): ₹ 8,426.52
Total Price: ₹ 55,240.52
Chemical Name or Material
(2 S,4 R)-1-(-2-(2-(4-((4 '-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1 '-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxami
Quantity
5 mg
Molecular Formula
C53H56F3N7O7S2
CAS
1973403-00-7
Target
Active Degraders
Purity
0.98
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
ARCC 4 | -- | ₹ 3,293.00 - ₹ 24,386.00 | ||
ARCC-4 | -- | ₹ 33,820.00 - ₹ 2,58,100.00 | ||
1973403-00-7 | ARCC 4 | -- | ₹ 16,287.00 - ₹ 1,04,130.00 |
Related Products
Description
- ARCC 4 is a potent and selective androgen receptor (AR) PROTAC™ Degrader (DC50 = 5 nM)
- Comprises an androgen receptor antagonist, enzalutamide, joined by a linker to a VHL E3 ligase ligand
- Brings about degradation of ARs in VCaP and LNCaP prostate cancer cell lines (Dmax = 98% at 12h) in a proteasome-dependent manner, and inhibits cell proliferation
- Also degrades clinically relevant AR mutants expressed in HEK293T cells
- Exhibits no significant effect on glucocorticoid, estrogen or progesterone receptors at concentrations inducing AR degradation
- ARCC 4 negative control (Cat
- No
- 7255) also available
- PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C