72-825

Tocris™ Bortezomib

Manufacturer: Fischer Scientific

CAS Number: 179324-69-7

Select a Size

Pack Size SKU Availability Price
Each of 1 72-825-Each-of-1 In Stock ₹ 12,095.10

72-825 - Each of 1

₹ 12,095.10

In Stock

Quantity

1

Base Price: ₹ 12,095.10

GST (18%): ₹ 2,177.118

Total Price: ₹ 14,272.218

Chemical Name or Material

B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid

Quantity

5 mg

Molecular Formula

C19H25BN4O4

CAS

179324-69-7

Target

Proteasome Inhibitors

Purity

0.98

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Description

  • Bortezomib is a high affinity proteasome inhibitor (Ki = 0.6 nM)
  • Inhibits growth of multiple myeloma (MM) cell lines (IC50 values in <50 nM range); induces apoptosis in MM cell lines and MM patient derived cells, including p53 mutant cell lines
  • Decreases adherence of MM cells lines to bone marrow stromal cells (BMSCs)
  • Acts synergistically with dexamethasone (Cat
  • No
  • 1126)
  • Also cytotoxic in MCF-7 breast cancer cell line (IC50 = 50 nM).

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C