7235823
Tocris™ Bortezomib
High affinity proteasome inhibitor
Manufacturer: Fischer Scientific
CAS Number: 179324-69-7
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Chemical Name or Material
B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Target
Proteasome Inhibitors
Purity
0.98
CAS
179324-69-7
Molecular Formula
C19H25BN4O4
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris™ Bortezomib | -- | ₹ 50,685.50 | ||
Tocris™ Bortezomib | -- | ₹ 12,095.10 | ||
Medchemexpress LLC HY-10227 100mg , Bortezomib CAS:179324-69-7 Purity:>98% | -- | ₹ 16,821.00 | ||
Medchemexpress LLC HY-10227 50mg , Bortezomib CAS:179324-69-7 Purity:>98% | -- | ₹ 10,092.60 | ||
Apexbio Technology LLC Bortezomib (PS-341), 10mg. Cas: 179324-69-7 MFCD: MFCD09056737. Proteasome Inhibitor | -- | ₹ 5,340.00 | ||
Ubpbio A reversible proteasome inhibitor approved by FDA for the treatment of relapsed multiple myeloma. CAS# 179324-69-7, > 98% purity | -- | ₹ 12,282.00 | ||
Selleck Chemical LLC Bortezomib (PS-341) 100mg 179324-69-7 LDP-341, MLM341 | -- | ₹ 69,170.80 | ||
Avachem Scientific LLC Bortezomib, 179324-69-7, MFCD09056737, 10mg | -- | ₹ 4,249.75 | ||
Selleck Chemical LLC Bortezomib (PS-341) 25mg 179324-69-7 LDP-341, MLM341 | -- | ₹ 28,836.00 | ||
AdipoGen Bortezomib, 179324-69-7, MFCD09056737, 5 mg | -- | ₹ 5,629.25 |
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Description
- Bortezomib is a high affinity proteasome inhibitor (Ki = 0.6 nM)
- Inhibits growth of multiple myeloma (MM) cell lines (IC50 values in <50 nM range); induces apoptosis in MM cell lines and MM patient derived cells, including p53 mutant cell lines
- Decreases adherence of MM cells lines to bone marrow stromal cells (BMSCs)
- Acts synergistically with dexamethasone (Cat
- No
- 1126)
- Also cytotoxic in MCF-7 breast cancer cell line (IC50 = 50 nM).
SAFETY INFORMATION
- Recommended Storage : Store at -20°C