860493P
1-deoxysphinganine
Manufacturer: Sigma Aldrich
CAS Number: 196497-48-0
Synonym(S): 1-deoxysphinganine (m18:0)
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | 860493P-1-MG | In Stock | ₹ 32,096.13 |
| 10 MG | 860493P-10-MG | In Stock | ₹ 1,28,362.85 |
860493P - 1 MG
In Stock
Quantity
1
Base Price: ₹ 32,096.13
GST (18%): ₹ 5,777.303
Total Price: ₹ 37,873.433
form
powder
packaging
pkg of 1 × 1 mg (860493P-1mg)pkg of 1 × 10 mg (860493P-10mg)
manufacturer/tradename
Avanti Polar Lipids 860493P
lipid type
bioactive lipidssphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
C[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C18H39NO/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17(2)19/h17-18,20H,3-16,19H2,1-2H3/t17-,18+/m0/s1
InChI key
YRYJJIXWWQLGGV-ZWKOTPCHSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Spisulosine | -- | ₹ 24,386.00 | ||
196497-48-0 | (2S,3R)-2-Aminooctadecan-3-ol | -- | ₹ 9,434.00 - ₹ 73,959.00 |
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Description
- General description: 1-deoxysphinganine is synthesized by the condensation of palmitic acid with alanine or glycine in the presence of enzyme serine palmitoyltransferase (SPT).[1] It is metabolized to 1-deoxyceramides.[2]
- Application: 1-deoxysphinganine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line.[3] It is also suitable for use as a neurotoxic agent in human CD8+ T cells.[4]
- Biochem/physiol Actions: 1-deoxysphinganine elicits cytotoxicity towards dorsal root ganglion (DRG) neurons by disrupting the neuronal cytoskeleton formation.[3] High levels of 1-deoxysphinganine in diabetic patients may contribute to the reduction of pancreatic β cell functionality.[1] In hereditary sensory and autonomic neuropathy type I, mutation in the serine palmitoyltransferase gene results in altered substrate specificity, resulting in the accumulation of 1-deoxysphinganine.[4]
- Packaging: 5 mL Amber Glass Screw Cap Vial (860493P-10mg)