Mouse PTEN (aa 252-269), Synthetic Peptide, Invitrogen™

Description

• Mouse PTEN (residues 252-269) Synthetic Peptide, PEP-284, from Invitrogen
• PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency
• The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase
• It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases
• Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates
• PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway
• PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation
• Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue
• The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability
• This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, PTEN, catalog &Num PA1-808
• Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (∽70-fold) for competitive inhibition of antibody-protein binding reactions.Reconstitute with 0.1 mL of distilled water.