G3381

Geldanamycin from Streptomyces hygroscopicus

≥98% (HPLC), powder

Manufacturer: Sigma Aldrich

CAS Number: 30562-34-6

Synonym(S): NSC 122750

Select a Size

Pack Size SKU Availability Price
1 MG G3381-1-MG In Stock ₹ 73,425.98

G3381 - 1 MG

₹ 73,425.98

In Stock

Quantity

1

Base Price: ₹ 73,425.98

GST (18%): ₹ 13,216.676

Total Price: ₹ 86,642.656

sterility

non-sterile

Quality Level

300

Assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: soluble

antibiotic activity spectrum

neoplastics

Mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O

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Description

  • General description: Chemical structure: benzenoid
  • Biochem/physiol Actions: Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
  • Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

SAFETY INFORMATION

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves