Cyclosporine
Pharmaceutical Secondary Standard; Certified Reference Material
Manufacturer: Supelco
CAS Number: 59865-13-3
Synonym(S): Cyclosporin A, Antibiotic S 7481F1, Cyclosporine
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 500 MG | PHR1092-500-MG | In Stock | ₹ 18,175.18 |
PHR1092 - 500 MG
In Stock
Quantity
1
Base Price: ₹ 18,175.18
GST (18%): ₹ 3,271.532
Total Price: ₹ 21,446.712
grade
certified reference materialpharmaceutical secondary standard
Quality Level
300
Agency
traceable to Ph. Eur. C2163000traceable to USP 1158504
API family
cyclosporine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitablegas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
-10 to -25°C
SMILES string
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Sigma Aldrich Fine Chemicals Biosciences Ciclosporin European Pharmacopoeia (EP) Reference Standard | 59865-13-3 | MFCD00274558 | | -- | ₹ 24,531.07 | ||
Cyclosporine Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™ | -- | ₹ 24,074.50 | ||
Sigma Aldrich Fine Chemicals Biosciences Cyclosporin A | 59865-13-3 | MFCD00274558 | 5mg | -- | ₹ 32,925.55 | ||
Sigma Aldrich Fine Chemicals Biosciences Cyclosporin A, Ready Made Solution 1 mg/mL in DMSO (0.2 μm-filtered) | 59865-13-3 | 1ml | -- | ₹ 17,880.10 | ||
eMolecules Medchem Express / Cyclosporin A / 100mg / 446273016 / HY-B0579 / / 59865-13-3 / MFCD00274558 / 1202.635 / C62H111N11O12 | -- | ₹ 7,860.48 | ||
Enzo Life Sciences Cyclosporin A (500mg). CAS: 59865-13-3 | -- | ₹ 31,626.15 | ||
Cyclosporin A solution | -- | ₹ 27,038.90 | ||
Cyclosporine | -- | ₹ 1,51,182.00 | ||
Ciclosporin for system suitability A | -- | ₹ 14,970.98 | ||
Ciclosporin | -- | ₹ 16,516.80 |
Description
- General description: Cyclosporine is a lipophilic immunosuppressive peptide with antifungal and anti-inflammatory properties.[1] It selectively inhibits the production of cytokines involved in T-lymphocyte activation in response to antigen stimulation.[2] It is widely used to prevent transplanted organ rejection and for the treatment of various autoimmune diseases.[3]
- Application: These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.Cyclosporine may be used as a reference standard for the determination of cyclosporine in biological samples by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method.[4]
- Biochem/physiol Actions: A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
- Analysis Note: These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
- Other Notes: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
- Footnote: To see an example of a Certificate of Analysis for this material enter LRAB3757 in the slot below. This is an example certificate only and may not be the lot that you receive.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
WGK
WGK 3