860492P
Sphingosine-1-Phosphate (d18:1)
Manufacturer: Sigma Aldrich
CAS Number: 26993-30-6
Synonym(S): D-erythro-sphingosine-1-phosphate
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 MG | 860492P-1-MG | In Stock | ₹ 32,096.13 |
| 5 MG | 860492P-5-MG | In Stock | ₹ 90,226.38 |
| 25 MG | 860492P-25-MG | In Stock | ₹ 2,32,488.53 |
860492P - 1 MG
In Stock
Quantity
1
Base Price: ₹ 32,096.13
GST (18%): ₹ 5,777.303
Total Price: ₹ 37,873.433
form
powder
packaging
pkg of 1 × 1 mg (860492P-1mg)pkg of 1 × 25 mg (860492P-25mg)pkg of 1 × 5 mg (860492P-5mg)
manufacturer/tradename
Avanti Polar Lipids
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O
InChI
1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
InChI key
DUYSYHSSBDVJSM-KRWOKUGFSA-N
Other Options
Related Products
Description
- General description: Sphingosine-1-phosphate (S1P), a sphingolipid, is an important cellular metabolite and signaling lipid in animal cells. It has also been found in yeasts and plants.[1] Sphingosine kinases (SPKs) catalyzes the synthesis of S1P from spingosine[2] and regulates S1P levels.[3] It is the end product of ceramide catabolism and is metabolized to phosphoethanolamine and hexadecenal by S1P lyase. S1P is produced in endothelial cells.[4]
- Application: Sphingosine-1-Phosphate (d18:1) has been used:as an internal standard in high performance liquid chromatography (HPLC) for the quantification of plasma lipid sphingosine-1-phosphate(S1P)[5]to evaluate its chemotactic response of auto reactive immature B cells[6]to test its effect on autophagy and preconditioning in oxygen and glucose deprived neurons[3]
- Biochem/physiol Actions: Sphingosine 1-phosphate (S1P) is a signaling molecule and an intracellular messenger, crucial for the physiological processes. It is implicated in the pathogenesis of osteoporosis, cancer, atherosclerosis and diabetes.[2] S1P regulates skin dendritic cells and keratinocytes, and its anti-inflammatory functionality is useful in treating atopic dermatitis.[4] S1P coordinates T lymphocytes circulation in lymph, plasma and tissue by interacting with G-protein coupled receptors (GPCRS).[6] S1P is a high affinity ligand for sphingosine-1-phosphate receptor (S1P1−5).[7]
- Packaging: 5 mL Amber Glass Screw Cap Vial (860492P-1mg)
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable