P3415

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester

≥95%, powder

Manufacturer: Sigma Aldrich

CAS Number: 68181-17-9

Synonym(S): N-Succinimidyl 3-(2-pyridyldithio)propionate, SPDP

Select a Size

Pack Size SKU Availability Price
5 MG P3415-5-MG In Stock ₹ 6,354.28
25 MG P3415-25-MG In Stock ₹ 19,420.05
100 MG P3415-100-MG In Stock ₹ 58,433.35

P3415 - 5 MG

₹ 6,354.28

In Stock

Quantity

1

Base Price: ₹ 6,354.28

GST (18%): ₹ 1,143.77

Total Price: ₹ 7,498.05

Quality Level

200

Assay

≥95%

form

powder

reaction suitability

reagent type: cross-linking reagent

mp

84-86 °C (lit.)

solubility

acetone: 50 mg/mLDMF: soluble

functional group

NHS ester

storage temp.

−20°C

SMILES string

O=C(CCSSC1=NC=CC=C1)ON2C(CCC2=O)=O

InChI

1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2

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Description

  • General description: 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.[1][2]
  • Application: 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.It has been used for antibody conjugation and as a protein cross-linker.[3][4]

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves