Nutlin-3a
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 675576-98-4
Synonym(S): (-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one, (-)-Nutlin-3, 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one, 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-Piperazinone, Nutlin 3a
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML0580-5-MG | In Stock | ₹ 34,754.10 |
| 25 MG | SML0580-25-MG | In Stock | ₹ 95,915.10 |
SML0580 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 34,754.10
GST (18%): ₹ 6,255.738
Total Price: ₹ 41,009.838
ligand
nutlin-3a
Quality Level
100
Assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -130 to -154° (c=0.5, CDCl3)
reaction suitability
reagent type: ligand
color
white to beige
solubility
DMSO: 5 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Medchemexpress LLC HY-10029 50mg , Nutlin-3a CAS:675576-98-4 Purity:>98% | -- | ₹ 80,740.80 | ||
Sigma Aldrich Fine Chemicals Biosciences Nutlin-3a >=98% (HPLC) | 675576-98-4 | MFCD14636430 | 25MG | -- | ₹ 1,27,074.20 | ||
Medchemexpress LLC HY-10029 10mg Medchemexpress, Nutlin-3a CAS:675576-98-4 Purity:>98% | -- | ₹ 19,063.80 | ||
Selleck Chemical LLC Nutlin-3a 25mg 675576-98-4 (-)-Nutlin-3 | -- | ₹ 61,961.80 | ||
Apexbio Technology LLC small-molecule MDM2 inhibitor 675576-98-4. MFCD14636430 | -- | ₹ 11,748.00 | ||
4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone | -- | ₹ 2,403.00 - ₹ 91,581.00 | ||
Nutlin-3a | -- | ₹ 11,748.00 - ₹ 1,15,700.00 | ||
675576-98-4 | 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone | -- | ₹ 7,476.00 - ₹ 58,028.00 |
Related Products
Description
- Application: Nutlin-3a has been used as a tumor suppressor p53(TP53) stabilizer and as an inhibitor of the mouse double minute 2 homolog (MDM2)–p53 interaction.[1][2][3][4]
- Biochem/physiol Actions: Nutlin-3a [(-)-Nutlin] is a more potent diastereoisomer of racemic MDM2 antagonist Nutlin-3. It was called enantiomer-a since it elutes as the first peak from chiral purification of racemic nutlin-3. Nutlin-3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53. Nutlin-3a is 150 times more potent than Nutlin-3b.
- Features and Benefits: This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable