200006968
Tocris Bioscience™ PIK 90
Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation
Manufacturer: Fischer Scientific
CAS Number: 677338-12-4
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Chemical Name or Material
N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide
Target
PI 3-Kinase Inhibitors
Purity
0.98
CAS
677338-12-4
Molecular Formula
C18H17N5O3
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ PIK 90 | -- | ₹ 13,990.80 | ||
Tocris Bioscience™ PIK 90 | -- | ₹ 58,651.00 | ||
Selleck Chemical LLC PIK-90 5mg 677338-12-4 | -- | ₹ 7,476.00 | ||
677338-12-4 | PIK-90 | -- | ₹ 1,068.00 - ₹ 20,915.00 |
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Description
- PIK 90 is a potent inhibitor of PI 3-K α/γ/δ kinases (IC50 = 11, 18, 47, 58 and 64 nM against p110α, p110γ, PI 3-KC2α, p110δ and PI 3-KC2α, respectively) as well as PIKKs (IC50 = 13 nM against DNA-PK)
- It inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells
- It suppresses insulin-stimulated phosphorylation of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes in vitro and prevents insulin-induced blood glucose reduction in mice in vivo
- PIK 90 can be used in combination with other small molecules and proteins for mesendoderm induction in protocols to differentiate iPSCs into organ-specific mesenchyme.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C