52-851-0
Tocris Bioscience™ ZLN 024 hydrochloride
Manufacturer: Fischer Scientific
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Chemical Name or Material
2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]pyrimidine hydrochloride
Target
AMPK Activators
Formula Weight
361.69
Quantity
10 mg
Molecular Formula
C13H13BrN2OS.HCl
Purity
>99%
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Description
- ZLN 024 hydrochloride is an allosteric AMP-activated protein kinase (AMPK) activator; allosterically stimulates active AMPK heterotrimers, increasing the activity of α1β1γ1 by 1.5-fold and α2β1γ1 by 1.7-fold (EC50 values are 0.42 and 0.95 μM, respectively)
- Inhibits dephosphorylation of AMPK Thr-172 by PP2Cα
- Stimulates glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio
- Also decreases fatty acid synthesis and glucose output in primary hepatocytes
- Improves glucose tolerance and decreases cholesterol content in db/db mice.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C