59-561-0
Tocris Bioscience™ NF 1819
Manufacturer: Tocris Bioscience™
CAS Number: 1881244-28-5
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Chemical Name or Material
(3R,4S)-rel-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H)-1,2,4-triazol-1-carbonyl)-4-piperidinyl]-2-azetidinone
Assay Percent Range
>98%
Molecular Formula
C24H22FN5O4
CAS
1881244-28-5
Quantity
10 mg
Formula Weight
Observed MW: 463.46
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
1881244-28-5 | (3R,4S)-rel-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H)-1,2,4-triazol-1-carbonyl)-4-piperidinyl]-2-azetidinone | -- | ₹ 14,329.00 - ₹ 1,15,255.00 |
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Description
- NF 1819 is a potent and selective irreversible MAGL inhibitor (IC50 values are 0.25 and 7.4 nM at rMAGL and hMAGL, respectively)
- Exhibits 389-fold selectivity over hFAAH and exhibits minimal binding at CB receptors (IC50 > 10 μM)
- Alleviates symptoms in a MS in vivo model
- Exhibits analgesic effects in an acute inflammatory pain model in vivo
- Ameliorates neuropathic hypersensitivity induced by oxaliplatin (Cat
- No
- 2623)
- Displays high membrane permeability and brain penetrant.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C