61-992-5

Tocris Bioscience™ BAY 876

Manufacturer: Tocris Bioscience™

CAS Number: 1799753-84-6

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Chemical Name or Material

N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide

Quantity

25 mg

Purity

98%

CAS

1799753-84-6

Molecular Formula

C24H16F4N6O2

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Description

  • BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively)
  • BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells
  • In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo
  • This compound is cell permeable and orally bioavailable.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C