7082172

Tocris Bioscience™ TC-G 1005

Potent and selective GPBA receptor (TGR5) agonist

Manufacturer: Fischer Scientific

CAS Number: 1415407-60-1

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Chemical Name or Material

TC-G 1005

Synonym

(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone

Molecular Formula

C25H25N3O2

Physical Form

Solid

Purity

>98%

CAS

1415407-60-1

Solubility

Soluble to 100mM in DMSO and to 100mM in ethanol

Formula Weight

399.48

Product Type

Bioactive Small Molecule

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Description

  • Potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5)
  • Selective for TGR5 over FXR (farnesoid X receptor)
  • Increases plasma GLP-1 levels and reduces blood glucose in mice
  • Orally available.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C