7082195

Tocris Bioscience™ KRIBB11

HSF1 inhibitor

Manufacturer: Fischer Scientific

CAS Number: 342639-96-7

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Chemical Name or Material

KRIBB11

Synonym

N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine

Molecular Formula

C13H12N6O2

Physical Form

Solid

Purity

>99%

CAS

342639-96-7

Solubility

Soluble to 100mM in DMSO

Formula Weight

284.27

Product Type

Bioactive Small Molecule

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Description

  • Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM)
  • Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat
  • No
  • 1368) and 17-AAG (Cat
  • No
  • 1515)
  • Blocks downstream induction of HSP27 and HSP70
  • Inhibits tumor growth in vivo .

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C