7110921

Tocris Bioscience™ Bexarotene

Potent and selective RXR agonist

Manufacturer: Fischer Scientific

CAS Number: 153559-49-0

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Chemical Name or Material

4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

Synonym

LGD 1069

Molecular Formula

C24H28O2

Purity

>99%

CAS

153559-49-0

Target

Retinoid X Receptor Agonists

Formula Weight

348.48

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Description

  • Potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively)
  • Exhibits >300-fold selectivity for RXR over RAR receptors
  • Inhibits tumor cell invasion and migration in vitro , and inhibits metastasis and angiogenesis in mouse models
  • Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.

SAFETY INFORMATION

  • Recommended Storage : Store at 4°C