7114679
Tocris Bioscience™ Lonafarnib
Potent farnesyl transferase inhibitor
Manufacturer: Fischer Scientific
CAS Number: 193275-84-2
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Chemical Name or Material
4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
Assay Percent Range
>98%
Formula Weight
Observed MW: 638.82
CAS
193275-84-2
Molecular Formula
C27H31Br2ClN4O2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ Lonafarnib | -- | ₹ 17,728.80 | ||
Tocris Bioscience™ Lonafarnib | -- | ₹ 73,425.00 | ||
Medchemexpress LLC HY-15136 10mg , Lonafarnib CAS:193275-84-2 Purity:>98% | -- | ₹ 17,755.50 | ||
Selleck Chemical LLC Lonafarnib 5mg 193275-84-2 SCH66336 | -- | ₹ 18,156.00 | ||
Sigma Aldrich Fine Chemicals Biosciences Lonafarnib | 193275-84-2 | MFCD06795138 | 5mg | -- | ₹ 15,045.45 |
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Description
- Potent farnesyl transferase inhibitor (IC50 = 1.9 nM)
- Inhibits farnesylation of RAS
- Also inhibits Pgp transport (IC50 < 3 μM) and increases potency and anticancer activity when used in conjunction with cytotoxic Pgp substrates
- Inhibits neovascularization by affecting cell motility
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C