7146025

Tocris Bioscience™ SLM 6031434 hydrochloride

Selective sphingosine kinase 2 (Sphk2) inhibitor

Manufacturer: Fischer Scientific

CAS Number: 1897379-34-8

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Chemical Name or Material

(2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride

CAS

1897379-34-8

Molecular Formula

C22H30F3N5O2.HCl

Purity

98%

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Description

  • Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2)
  • Exhibits 40-fold selectivity for Sphk2 over Sphk1
  • Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice .

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C