7182960
Tocris Bioscience™ VU 0424465
Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity
Manufacturer: Fischer Scientific
CAS Number: 1428630-85-6
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Chemical Name or Material
5-[2-(2-(3-Fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-2-pyridinecarboxamide
CAS
1428630-85-6
Molecular Formula
C19H19FN2O2
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ VU 0424465 | -- | ₹ 23,848.44 | ||
Tocris Bioscience™ VU 0424465 | -- | ₹ 99,420.12 |
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Description
- Potent mGlu5 positive allosteric modulator (EC50 = 1.5 nM) and agonist (EC50 = 171 nM; maximum effect is 65% that of glutamate)
- Binds allosteric site with high affinity (Ki = 11.8 nM)
- Increases maximum response to glutamate by 30%
- Exhibits bias towards signaling via IP1 and ERK1/2 over iCa2+ in HEK293 and neuronal cells, and activates Gs in HEK 293 cells
- Induces epileptiform activity in CA3 hippocampal neurons in vitro and convulsions in vivo .