7199096

Tocris™ NNC 0640

Negative allosteric modulator of glucagon and GLP-1 receptors

Manufacturer: Fischer Scientific

CAS Number: 307986-98-7

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Chemical Name or Material

4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2 H-tetrazol-5-ylbenzamide

Target

Glucagon-Like Peptide 1 Receptor Modulators

Purity

98%

CAS

307986-98-7

Molecular Formula

C29H31N7O4S

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Description

  • Negative allosteric modulator of glucagon receptors (pKi = 7.4)
  • Binds to external surface of the transmembrane domain
  • Also negative allosteric modulator of glucagon-like peptide 1 (GLP-1) receptor
  • Inhibits GLP-1-mediated cAMP accumulation in vitro .

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C