7199103
Tocris™ DL 175
Potent and selective GPR84 agonist
Manufacturer: Fischer Scientific
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Chemical Name or Material
3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
Target
Free Fatty Acid Receptor Agonists
Molecular Formula
C17H14ClNO2
Purity
98%
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Description
- DL 175 is a potent and selective GPR84 biased agonist (EC50 = 33 nM)
- Exhibits no significant activity in a panel of 168 other GPCRs
- Exhibits bias for G protein signaling pathways
- Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells
- Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C