7222996

Tocris Bioscience™ GPR52 Comp-43

GPR52 receptor antagonist

Manufacturer: Fischer Scientific

CAS Number: 1239987-91-7

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Chemical Name or Material

(2 E)-5-Phenyl-1-(2-thienyl)-2-penten-1-one

Target

Orphan 7-TM Receptor Antagonists

Purity

0.98

CAS

1239987-91-7

Molecular Formula

C15H14OS

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Description

  • Description GPR52 Comp-43 is a GPR52 receptor antagonist (IC50 = 0.63 μM)
  • The use of GPR52 Comp-43 in animal models of Huntington's Disease leads to degradation and reduction of soluble and aggregated mutant huntingtin protein in the striatum
  • It also reduces neuronal loss, promotes neuronal survival and improves motor functions in vivo
  • GPR52 Comp-43 is active in vitro and brain penetrant.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C