7237105
Tocris Bioscience™ JHU 37160
High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
Manufacturer: Fischer Scientific
CAS Number: 2369979-68-8
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Chemical Name or Material
8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Target
DREADD Activators
Purity
0.98
CAS
2369979-68-8
Molecular Formula
C19H20ClFN4
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ JHU 37160 | -- | ₹ 23,896.50 | ||
Tocris Bioscience™ JHU 37160 | -- | ₹ 1,00,570.00 | ||
eMolecules Medchem Express / JHU37160 / 5mg / 596608116 / HY-131881 / / 2369979-68-8 / [null] / 358.850 / C19H20ClFN4 | -- | ₹ 4,791.76 | ||
JHU37160 | -- | ₹ 3,115.00 - ₹ 21,805.00 | ||
2369979-68-8 | JHU 37160 | -- | ₹ 3,026.00 - ₹ 19,313.00 |
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Description
- JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro , respectively; EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in vitro , respectively)
- Displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21 (Cat
- No
- 5548)
- Selectively displaces [3H]clozapine from DREADDs in vivo , but not from other clozapine binding sites
- Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons
- Brain penetrant in mice, rats and non-human primates.
SAFETY INFORMATION
- Recommended Storage : Store at RT