7237103
Tocris Bioscience™ Deschloroclozapine
High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; rapidly blood brain barrier penetrant
Manufacturer: Fischer Scientific
CAS Number: 1977-07-07 00:00:00
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Chemical Name or Material
11-(4-Methyl-1-piperazinyl)-5 H-dibenzo[b,e][1,4 ]diazepine
Target
DREADD Activators
Purity
0.98
CAS
1977-07-07 00:00:00
Molecular Formula
C18H20N4
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ Deschloroclozapine | -- | ₹ 16,162.40 | ||
Tocris Bioscience™ Deschloroclozapine | -- | ₹ 67,996.00 |
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Description
- Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs (Ki values are 6.3 nM for hM3Dq and 4.2 nM for hM4Di, in vitro ; EC50 values are 0.13 nM for hM3Dq and 0.081 nM for hM4Di, in vitro )
- Derivative of clozapine (Cat
- No
- 0444)
- Exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N -oxide (CNO; Cat
- No
- 4936), and 50-fold greater affinity compared to DREADD agonist 21 (Cat
- No
- 5548)
- Displays low 'off-target' receptor binding (Ki >100 nM at majority of GPCRs, ion channels and transporters tested)
- Displays rapid (approx
- 10 minutes after i.p injection) binding and activation of hM3Dq and hM4Di in mice and non-human primates
- Induces spatial memory deficits in non-human primates expressing hM4Di in the prefrontal cortex.
SAFETY INFORMATION
- Recommended Storage : Store at RT