7249495

Tocris Bioscience™ Hh-Ag1.5

Potent and high affinity Smo receptor agonist

Manufacturer: Fischer Scientific

CAS Number: 612542-14-0

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Chemical Name or Material

3-Chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide

CAS

612542-14-0

Target

Smoothened

Molecular Formula

C28H26ClF2N3OS

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Description

  • Hh-Ag1.5 is a potent and high affinity Hedgehog (Hh) receptor agonist (EC50 = 1 nM; Ki values are 0.5 and 2.3 nM respectively, in a [3H]SAG-1.3 and [3H]Cyclopamine binding assay)
  • It is used in protocols for the chemical reprogramming of mouse embryonic fibroblasts into neural stem cells
  • Also induces differentiation of hiPSCs into skin-derived precursor cells, spinal motor neurons and spinal sensory neurons.

SAFETY INFORMATION

  • Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.