77-605-0

Tocris Bioscience™ Selinexor

Manufacturer: Fischer Scientific

CAS Number: 1393477-72-9

Select a Size

Pack Size SKU Availability Price
Each of 1 77-605-0-Each-of-1 In Stock ₹ 82,903.50

77-605-0 - Each of 1

₹ 82,903.50

In Stock

Quantity

1

Base Price: ₹ 82,903.50

GST (18%): ₹ 14,922.63

Total Price: ₹ 97,826.13

Chemical Name or Material

(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide

Quantity

50 mg

Molecular Formula

C17H11F6N7O

CAS

1393477-72-9

Target

Antiviral Compounds

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Description

  • Selinexor is an inhibitor of the exportin 1 (XPO1/CRM1) nuclear exporter
  • Shows selectivity for TNBC over ER-positive breast cancer cell lines (IC50 values are 11-550 nM and >1000 nM, respectively), and reduces growth of xenografts
  • Inhibits growth of thyroid cancer cell lines (IC50 = 150-500 nM), potentiates the anti-tumor effects of Olaparib (Cat
  • No
  • 7579) in ovarian cancer and breast cancer
  • Also a potent inhibitor of SARS-CoV-2 replication in vitro (EC50 = 10 nM) and downregulates the production of pro-inflammatory cytokines including TNF-α and IL-6.

SAFETY INFORMATION

  • Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.