61-561-0
Tocris Bioscience™ VH 298
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 61-561-0-Each-of-1 | In Stock | ₹ 32,974.50 |
61-561-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,974.50
GST (18%): ₹ 5,935.41
Total Price: ₹ 38,909.91
Product Type
Inhibitor
Molecular Formula
C27H33N5O4S
Content And Storage
Store at -20°C
Quantity
10 mg
Target Proteins
Ubiquitin Ligase (E3)
Formula Weight
523.65g/mol
For Use With (Application)
Ubiquitin Ligase (E3) Inhibitors
Related Products
Description
- High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM)
- Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response
- Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia
- Cell permeable
- Negative control cis VH 298 also available.