7112419
Tocris Bioscience™ VH 298
High-affinity inhibitor of VHL
Manufacturer: Fischer Scientific
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Product Type
Inhibitor
Molecular Formula
C27H33N5O4S
Content And Storage
Store at -20°C
Target Proteins
Ubiquitin Ligase (E3)
Formula Weight
523.65g/mol
For Use With (Application)
Ubiquitin Ligase (E3) Inhibitors
Related Products
Description
- High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM)
- Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response
- Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia
- Cell permeable
- Negative control cis VH 298 also available.