65-875

Tocris Bioscience™ TAK 242

Manufacturer: Tocris Bioscience™

CAS Number: 243984-11-4

Select a Size

Pack Size SKU Availability Price
Each of 1 65-875-Each-of-1 In Stock ₹ 26,388.50

65-875 - Each of 1

₹ 26,388.50

In Stock

Quantity

1

Base Price: ₹ 26,388.50

GST (18%): ₹ 4,749.93

Total Price: ₹ 31,138.43

Chemical Name or Material

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate

Quantity

5 mg

Formula Weight

361.82

CAS

243984-11-4

Molecular Formula

C15H17ClFNO4S

Purity

98%

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Description

  • TAK 242 is a toll-like receptor 4 (TLR4) signaling inhibitor
  • Binds to intracellular domain of TLR4
  • Inhibits LPS-induced cytokine production in vitro (IC50 values are 1.3, 1.3 and 3.2 nM for IL-6, TNFα and NO production)
  • Reduces lesion volume in a mouse model of cerebral cavernous malformations (CCMs)
  • Also attenuates increased cytokine levels in a mouse sepsis model, when given in combination with ceftazidime
  • Cell permeable.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C