PZ0307
PFI-4
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 900305-37-5
Synonym(S): N-(1,3-Dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide, N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy-benzamide, PF-05363047
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | PZ0307-5-MG | In Stock | ₹ 11,788.43 |
| 25 MG | PZ0307-25-MG | In Stock | ₹ 35,570.95 |
PZ0307 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 11,788.43
GST (18%): ₹ 2,121.917
Total Price: ₹ 13,910.347
Quality Level
100
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
room temp
SMILES string
CN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O
InChI
1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26)
InChI key
QCIJLRJBZDBVDB-UHFFFAOYSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Sigma Aldrich Fine Chemicals Biosciences PFI-4 >=98% (HPLC) | 900305-37-5 | 5MG | -- | ₹ 12,864.95 | ||
Apexbio Technology LLC Omaveloxolone (RTA-408) 5mg. 900305-37-5. MFCD14744412 | -- | ₹ 12,015.00 | ||
900305-37-5 | PFI-4 | -- | ₹ 3,560.00 - ₹ 82,147.00 |
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Description
- Biochem/physiol Actions: PFI-4 is an SGC chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) scaffolding protein BRPF1B. The BRPF proteins (BRPF1/2/3) assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. Mutations in MOZ, MORF, and BRPF1 have all been associated with cancer. BRPF1 exists in 2 different isoforms: BRPF1A and BRPF1B. PFI-4 specifically binds to BRPF1B with a Kd =13 nM as determined by ITC. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250nM, while showing no effect on BRPF1A. For full characterization details, please visit the PFI-4 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
- Features and Benefits: PFI-4 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable